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1

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

Omid Motabar, Ehud Goldin, William Leister, Ke Liu, Noel Southall, Wenwei Huang, Juan J. Marugan, Ellen Sidransky, Wei Zheng

Journal:

Analytical and Bioanalytical Chemistry

Year:

2012

Language:

english

File:

PDF, 350 KB

english, 2012

2

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

Sima, Ni, Li, Rong, Huang, Wei, Xu, Miao, Beers, Jeanette, Zou, Jizhong, Titus, Steven, Ottinger, Elizabeth A., Marugan, Juan J., Xie, Xing, Zheng, Wei

Journal:

Orphanet Journal of Rare Diseases

Year:

2018

Language:

english

File:

PDF, 4.67 MB

english, 2018

3

Validation and characterization of five distinct novel inhibitors of human cytomegalovirus

Kapoor, Arun, Ghosh, Ayan Kumar, Forman, Michael, Hu, Xin, Ye, Wenjuan, Southall, Noel, Marugan, Juan J, Keyes, Robert F, Smith, Brian C, Meyers, David J., Ferrer, Marc, Arav-Boger, Ravit

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 1.20 MB

english, 2020

4

The influence of chemotherapy on plasma coagulation and fibrinolytic systems in lung cancer patients

M. A. Ruiz, I. Marugan, A. Estellés, I. Navarro, F. España, V. Alberola, L. San Juan, J. Aznar, J. Garcia-Conde

Journal:

Year:

1989

Language:

english

File:

PDF, 584 KB

english, 1989

5

XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia

Vicent M. Guillem, Francisco Cervantes, Jesús Martínez, Alberto Alvarez-Larrán, María Collado, Mireia Camós, Anna Sureda, Margherita Maffioli, Isabel Marugán, Juan-Carlos Hernández-Boluda

Journal:

American Journal of Hematology

Year:

2010

Language:

english

File:

PDF, 124 KB

english, 2010

6

Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct-cannulated rats

Yanmin Chen, Deping Cheng, Juan Jose Marugan, Carl Manthey, Bruce Tomczuk, Norman Huebert

Journal:

Biopharmaceutics & Drug Disposition

Year:

2008

Language:

english

File:

PDF, 201 KB

english, 2008

7

Structure-Based Design, Synthesis, and Biological Evaluation of Novel 1,4-Diazepines as HDM2 Antagonists.

Juan Jose Marugan, et al. et al.

Journal:

Year:

2005

File:

PDF, 25 KB

2005

8

Dynamics of large turbulent structures in a steady breaker

Javier Rodríguez-Rodríguez, Carolina Marugán-Cruz, Alberto Aliseda, Juan Carlos Lasheras

Journal:

Experimental Thermal and Fluid Science

Year:

2011

Language:

english

File:

PDF, 588 KB

english, 2011

9

A novel non nucleoside compound with high in vitro anti-HIV-1 activity. Absolute stereochemistry determination

Jesús A. De la Fuente, Juan J. Marugán, Sue S. Cross, Alfonso F. Mateos, Santiago García, Amador Menéndez

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 197 KB

english, 1995

10

Design, synthesis, and biochemical evaluation of novel αvβ3 integrin ligands

Juan Jose Marugan, Kristin D Haslow, Carl Crysler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 250 KB

english, 2004

11

Non-peptidic αvβ3 antagonists containing indol-1-yl propionic acids

Kristi Leonard, Wenxi Pan, Beth Anaclerio, Joan M. Gushue, Zihong Guo, Renee L. DesJarlais, Marge A. Chaikin, Jennifer Lattanze, Carl Crysler, Carl L. Manthey, Bruce E. Tomczuk, Juan Jose Marugan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

12

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists

Pierre Raboisson, Juan José Marugán, Carsten Schubert, Holly K. Koblish, Tianbao Lu, Shuyuan Zhao, Mark R. Player, Anna C. Maroney, Rolanda L. Reed, Norman D. Huebert, Jennifer Lattanze, Daniel J. Par

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

13

A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s

Nalin L. Subasinghe, Jeremy M. Travins, Farah Ali, Hui Huang, Shelley K. Ballentine, Juan José Marugán, Ehab Khalil, Heather R. Hufnagel, Roger F. Bone, Renee L. DesJarlais, Carl S. Crysler, Nisha Nin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 165 KB

english, 2006

14

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo, Karen L. Milkiewicz, Juan José Marugán, Pierre Raboisson, Carsten Schubert, Holly K. Koblish, Shuyuan Zhao, Carol F. Franks, Jennifer Lattanze, Theod

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 346 KB

english, 2006

15

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

Juan Jose Marugan, Kristi Leonard, Pierre Raboisson, Joan M. Gushue, Raul Calvo, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Carsten Schubert, Anna C. Maron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 229 KB

english, 2006

16

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

Kristi Leonard, Juan Jose Marugan, Pierre Raboisson, Raul Calvo, Joan M. Gushue, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Anna C. Maroney, Tianbao Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

17

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

Bryan T. Mott, Cordelle Tanega, Min Shen, David J. Maloney, Paul Shinn, William Leister, Juan J. Marugan, James Inglese, Christopher P. Austin, Tom Misteli, Douglas S. Auld, Craig J. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 715 KB

english, 2009

18

Novel potent and selective αvβ3/αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin

Pierre Raboisson, Carl L. Manthey, Margery Chaikin, Jennifer Lattanze, Carl Crysler, Kristi Leonard, Wenxi Pan, Bruce E. Tomczuk, Juan José Marugán

Journal:

European Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 598 KB

english, 2006

19

Identification of novel short chain 4-substituted indoles as potent αvβ3 antagonist using structure-based drug design

Pierre Raboisson, Renee L. DesJarlais, Rolanda Reed, Jennifer Lattanze, Margery Chaikin, Carl L. Manthey, Bruce E. Tomczuk, Juan José Marugán

Journal:

European Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 700 KB

english, 2007

20

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

Juan J. Marugan, Wei Zheng, Omid Motabar, Noel Southall, Ehud Goldin, Ellen Sidransky, Ronald A. Aungst, Ke Liu, Subir Kumar Sadhukhan, Christopher P. Austin

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.81 MB

english, 2010

21

Sustained complete molecular remission after imatinib discontinuation due to severe aplastic anemia

Juan-Carlos Hernández-Boluda, María Collado, Desamparados Roda, Paula Amat, Mar Tormo, Isabel Marugán

Journal:

Leukemia Research

Year:

2009

Language:

english

File:

PDF, 94 KB

english, 2009

22

Two high-throughput screening assays for aberrant RNA–protein interactions in myotonic dystrophy type 1

Catherine Z. Chen, Krzysztof Sobczak, Jason Hoskins, Noel Southall, Juan J. Marugan, Wei Zheng, Charles A. Thornton, Christopher P. Austin

Journal:

Analytical and Bioanalytical Chemistry

Year:

2012

Language:

english

File:

PDF, 530 KB

english, 2012

23

Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors

Yimin Qian, Juan Jose Marugan, Renae D. Fossum, Andreas Vogt, Said M. Sebti, Andrew D. Hamilton *

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 291 KB

english, 1999

24

Prognostic factors in patients with isolated recurrences of breast cancer (stage IV-NED)

Oscar Juan, Ana Lluch, Laura de Paz, Felipe Prósper, Pilar Azagra, Isabel Marugán, Angel Martínez-agulló, Javier Garcia-conde

Journal:

Breast Cancer Research and Treatment

Year:

1999

Language:

english

File:

PDF, 54 KB

english, 1999

25

Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

Patnaik, Samarjit, Zheng, Wei, Choi, Jae H., Motabar, Omid, Southall, Noel, Westbroek, Wendy, Lea, Wendy A., Velayati, Arash, Goldin, Ehud, Sidransky, Ellen, Leister, William, Marugan, Juan J.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.38 MB

english, 2012

26

A high-throughput sphingomyelinase assay using natural substrate

Xu, Miao, Liu, Ke, Southall, Noel, Marugan, Juan J., Remaley, Alan T., Zheng, Wei

Journal:

Analytical and Bioanalytical Chemistry

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

27

Study of the first step of the Mn2O3/MnO thermochemical cycle for solar hydrogen production

Javier Marugán, Juan A. Botas, Mariana Martín, Raúl Molina, Carolina Herradón

Journal:

International Journal of Hydrogen Energy

Year:

2012

Language:

english

File:

PDF, 1.30 MB

english, 2012

28

A functional radioreceptor assay of alpha-V-beta-3 (αvβ3) inhibitors in plasma: Application as an ex vivo pharmacodynamic model

Margery A. Chaikin, Júan José Marugan, Gerald W. De Vries, Peter Baciu, Jeffrey Edelman, Ming Ni, Bruce E. Tomczuk, Wenxi Pan, Zihong Guo, Beth Anaclerio, Kristi Leonard, Stephen H. Eisennagel, Christ

Journal:

Journal of Biochemical and Biophysical Methods

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

29

Functional polymorphisms in SOCS1 and PTPN22 genes correlate with the response to imatinib treatment in newly diagnosed chronic-phase chronic myeloid leukemia

Vicent Guillem, Paula Amat, Francisco Cervantes, Alberto Alvarez-Larrán, Jose Cervera, Margherita Maffioli, Beatriz Bellosillo, María Collado, Isabel Marugán, Francisco Martínez-Ruiz, Juan-Carlos Hern

Journal:

Leukemia Research

Year:

2012

Language:

english

File:

PDF, 337 KB

english, 2012

30

Multi-Gram Scale Synthesis of FR180204

Patnaik, Samarjit, Dietz, Harry C., Zheng, Wei, Austin, Christopher, Marugan, Juan J.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 723 KB

english, 2009

31

Evaluation of Quinazoline Analogues as Glucocerebrosidase Inhibitors with Chaperone Activity

Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Westbroek, Wendy, Stubblefield, Barbara K., Sidransky, Ellen, Aungst, Ronald A., Lea, Wendy A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.61 MB

english, 2011

32

Low efficacy of NcGRA7, NcSAG4, NcBSR4 and NcSRS9 formulated in poly-ɛ-caprolactone against Neospora caninum infection in mice

Elena Jiménez-Ruiz, Gema Álvarez-García, Adriana Aguado-Martínez, Hesham Salman, Juan M. Irache, Virginia Marugán-Hernández, Luis M. Ortega-Mora

Journal:

Year:

2012

Language:

english

File:

PDF, 665 KB

english, 2012

33

155. High Throughput screen for identifying small molecule modulators of alpha-glucosidase for the potential treatment of Pompe disease

Wei Zheng, Omid Motabar, Ke Liu, Ehud Goldin, Noel Southall, Juan Marugan, Christopher Austin, Ellen Sidransky

Journal:

Molecular Genetics and Metabolism

Year:

2009

Language:

english

File:

PDF, 41 KB

english, 2009

34

The use of saposin C and phosphatidylserine in functional studies of glucocerebrosidase

Jae Choi, Omid Motabar, Wei Zheng, Juan Marugan, Ellen Sidransky, Ehud Goldin

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 56 KB

english, 2011

35

Cell-Based Evaluation of Small Molecules for Treatment of Pompe Disease

Wendy Westbroek, Ann Marie Gustafson, Juan Marugan, Jingbo Xiao, Wei Zheng, Arash Velayati, Ehud Goldin, Ellen Sidransky

Journal:

Molecular Genetics and Metabolism

Year:

2012

Language:

english

File:

PDF, 52 KB

english, 2012

36

Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice

Baxter, Laura L., Marugan, Juan J., Xiao, Jingbo, Incao, Art, McKew, John C., Zheng, Wei, Pavan, William J.

Journal:

Year:

2012

Language:

english

File:

PDF, 381 KB

english, 2012

37

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines As Antagonists of the Neuropeptide S Receptor

McCoy, Joshua G., Marugan, Juan J., Liu, Ke, Zheng, Wei, Southall, Noel, Huang, Wenwei, Heilig, Markus, Austin, Christopher P.

Journal:

ACS Chemical Neuroscience

Year:

2010

Language:

english

File:

PDF, 2.05 MB

english, 2010

38

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Childs-Disney, Jessica L., Stepniak-Konieczna, Ewa, Tran, Tuan, Yildirim, Ilyas, Park, HaJeung, Chen, Catherine Z., Hoskins, Jason, Southall, Noel, Marugan, Juan J., Patnaik, Samarjit, Zheng, Wei, Aus

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

39

Discovery, Synthesis, and Biological Evaluation of Novel SMN Protein Modulators

Xiao, Jingbo, Marugan, Juan J., Zheng, Wei, Titus, Steve, Southall, Noel, Cherry, Jonathan J., Evans, Matthew, Androphy, Elliot J., Austin, Christopher P.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.14 MB

english, 2011

40

M1902 Efficacy and Safety of Entecavir and/or Tenofovir in Hepatitis B Cirrhotic Patients

Miquel, Mireia, Martinez, Oscar Nuñez, Trapero-Marugan, Maria, Diaz-Sanchez, Antonio, Jimenez, Miguel, Arenas, Juan I., Palau, Antonio

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 125 KB

english, 2010

41

Structure–Activity Relationship of Imidazopyridinium Analogues as Antagonists of Neuropeptide S Receptor

Patnaik, Samarjit, Marugan, Juan J., Liu, Ke, Zheng, Wei, Southall, Noel, Dehdashti, Seameen J., Thorsell, Annika, Heilig, Markus, Bell, Lauren, Zook, Michelle, Eskay, Bob, Brimacombe, Kyle R., Austin

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

42

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Xiao, Jingbo, Huang, Zaohua, Chen, Catherine Z., Agoulnik, Irina U., Southall, Noel, Hu, Xin, Jones, Raisa E., Ferrer, Marc, Zheng, Wei, Agoulnik, Alexander I., Marugan, Juan J.

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 534 KB

english, 2013

43

The use of primary myotubes and fibroblasts for the evaluation of pharmacological chaperone therapy in Pompe disease

Westbroek, Wendy, Tamargo, Rafael J., Xiao, Jingbo, Soska, Rebecca, Valenzano, Kenneth J., Goldin, Ehud, Khanna, Richie, Marugan, Juan J., Sidransky, Ellen

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 63 KB

english, 2013

44

Study of the hydrogen production step of the Mn2O3/MnO thermochemical cycle

Marugán, Javier, Botas, Juan A., Molina, Raúl, Herradón, Carolina

Journal:

International Journal of Hydrogen Energy

Year:

2014

Language:

english

File:

PDF, 822 KB

english, 2014

45

The development and evaluation of a macrophage model of Gaucher disease

Moaven, Nima, Aflaki, Elma, Stubblefield, Barbara K., Lopez, Grisel, Maniwang, Emerson, Westbroek, Wendy, Tayebi, Nahid, Marugan, Juan, Sidransky, Ellen

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 59 KB

english, 2013

46

A high-throughput screening assay using Krabbe disease patient cells

Ribbens, Jameson, Whiteley, Grace, Furuya, Hirokazu, Southall, Noel, Hu, Xin, Marugan, Juan, Ferrer, Marc, Maegawa, Gustavo H.B.

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

47

A high-throughput screening assay using Krabbe disease patient cells

Maegawa, Gustavo, Ribbens, Jameson, Whiteley, Grace, Furuya, Hirokazu, Southall, Noel, Hu, Xin, Marugan, Juan, Ferrer, Marc, Maegawa, Gustavo

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 60 KB

english, 2013

48

Non-inhibitory small molecule chaperones of glucocerebrosidase

Sidransky, Ellen, Sidransky, Ellen, Aflaki, Elma, Stubblefield, Barbara, Lopez, Grisel, Westbroek, Wendy, Tayebi, Nahid, Patnaik, Samarjit, Marugan, Juan

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 63 KB

english, 2013

49

Dihydroquinone Ansamycins: Toward Resolving the Conflict between Low in Vitro Affinity and High Cellular Potency of Geldanamycin Derivatives

Maroney, Anna C., Marugan, Juan J., Mezzasalma, Tara M., Barnakov, Alexander N., Garrabrant, Thomas A., Weaner, Larry E., Jones, William J., Barnakova, Ludmila A., Koblish, Holly K., Todd, Matthew J.,

Journal:

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

50

Design, Synthesis, and Biological Evaluation of Novel Potent and Selective α v β 3 /α v β 5 Integrin Dual Inhibitors with Improved Bioavailability. Selection of the Molecular Core

Marugán, Juan José, Manthey, Carl, Anaclerio, Beth, Lafrance, Lou, Lu, Tianbao, Markotan, Tom, Leonard, Kristi A., Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, Tomczuk, Bruce

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005